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If a new indication adds $500 million in annual revenue significant, but not a standalone blockbuster the forfeiture of independent patent term may be an acceptable cost for portfolio consolidation

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Though pathogenic RFK mutations are rare, animal models have shown that RFK loss results in impaired mitochondrial electron transport, NF-B activation, cognitive decline, and neuroinflammation, highlighting its disease relevance

Endocrine Journal 2021;68(6):739-742

When you ingest L-citrulline supplements or foods containing L-citrulline, the kidneys transform it into L-arginine, another nonessential amino acid known for increasing nitric oxide production

Author Contributions All authors contributed to the following during the development of this article: conception and design