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This cascade stimulates robust dendritic spinogenesis and new functional synaptogenesis in neuronal models, demonstrating neurotrophic potency up to seven orders of magnitude greater than Brain-Derived Neurotrophic Factor (BDNF)

This attachment initiates a cascade of intracellular signaling events, with insulin receptor substrate - 1 (IRS - 1) serving as a critical intermediary (Walte et al., 2024)

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