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IUBMB Life 2012;64(5):362-9

As a water-soluble vitamin, B12 is crucial for the formation of red blood cells, contributing to oxygen transport and preventing anemia-related fatigue

This analogue also demonstrated the most pronounced detoxifying effect towards cisplatin action, resulting in a decrease in the animal death from the acute cisplatin toxicity to 17% (in comparison with 50-67% for the control animals) and restoration of a number of cisplatin-sensitive biochemical blood parameters: decrease in the activity of aspartate aminotransferase and alanine aminotransferase and downregulation of the concentration of the final products of nitrogen exchange (creatinine and urea)

The validation cohort was analyzed on an Evosep One (Evosep Inc., Odense, Denmark) liquid chromatography system coupled to an Orbitrap Exploris 480 mass spectrometer (Thermo Fisher Scientific, Bremen, Germany)

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