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Researchers developing brain-targeting therapies for Sanfilippo have a few options: they can administer a therapy directly into the CNS, adapt a therapy to cross the BBB from the blood, or use a delivery vehicle to carry a therapy across the BBB

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Understanding these mechanisms helps explain why they are used for different conditions and why their side effects vary

Addition of R-lipoic acid increases ATP synthesis and aortic blood flow during reoxygenation after hypoxia while S-lipoic acid had no effect on ATP synthesis and improved blood flow at only 10-fold the effective dose of R-lipoic