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What MTHFR Does and What Goes Wrong When It Doesn't MTHFR (methylenetetrahydrofolate reductase) catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate (5,10-MTHF) to 5-methyltetrahydrofolate (5-MTHF) the predominant circulating form of folate and the methyl donor required by methionine synthase (MTR) to convert homocysteine back to methionine
[Accessed on September 8, 2017]
The cysteine thiol group (-SH) confers redox activity, enabling reversible oxidation-reduction cycling between reduced (GSH) and oxidized (GSSG) states
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This new complex initiates the caspase cascade reaction and activates downstream caspase-3 and caspase-7, thereby inducing apoptosis
