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Ensure that you empty your bowels before inserting the suppository Remove the plastic wrapping from one suppository Insert it gently into the rectum (narrow end first) past the sphincter muscles with your finger (use gloves or our suppository applicator for a cleaner insertion) A suppository needs to go in at least an inch past the rim/muscle of the rectum

Stomach acid is essential for breaking down protein into amino acids

Severe diarrhea, worsening fatty stools, or persistent cramping warrant immediate discussion with your provider

The slowing of gastric emptying is a key contributor to gastrointestinal side effects

Metabolic Adaptations to Weight Loss: A Brief Review. PubMed , 1 Oct

While major regulatory bodies like the FDA and EFSA deem it safe for the general public, the IARC has classified it as "possibly carcinogenic to humans" (Group 2B)