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on the contrary, it is dispersed heterogeneously, mainly as single cells, along the epithelium of the GI tract, from the stomach to the rectum with a defined cephalocaudal, crypt-to-villus in the small intestine and crypt-to-surface distribution in the colon ( Despite representing just 1% of the adult gut epithelium, in the last decade it has become clear that the EECs constitute the largest endocrine organ in mammalia ( Collectively, the EECs are responsible for the production of more than 30 different hormones that help to orchestrate the fate of the intermediary metabolism

The potential causes of this heterogeneity mainly include population characteristics, drug specificity, the intensity of lifestyle intervention, and the impact of comorbidities [50]

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The growth hormone produced as a result of Tesamorelin therapy enhances fat metabolism, leading to more efficient fat loss

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GCGR activation is hypothesised to increase energy expenditure and hepatic fat oxidation, though evidence remains largely preclinical