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Ops also induce activation of glutamatergic neurons with glutamate release that leads to activation of N -methyl-D-aspartate (NMDA) receptors (Milatovic et al., 2005)

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Another 2 months later, the patient exhibited a rebound response of 4 months duration with disappearance of pleural effusions, partial remission of the cutaneous metastases and stable size of the liver metastases

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