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The additional complexity is not arbitrary

Rosenstock J, Marquard J, Laffel LM et al (2018) Empagliflozin as adjunctive to insulin therapy in type 1 diabetes: the EASE trials

Alvarez-Villalobos NA, Trevino-Alvarez AM, Gonzalez-Gonzalez JG

Gastroenterology 2014

Clinical trials for oral semaglutide showed average weight loss of 10-15% of body weight over 68 weeks when combined with lifestyle changes

patients receiving ADMs saw noticeable spikes in the rate of discontinuation due to medication availability in January 2023 (5.3%) and June 2024 (4.8%), while patients receiving AOMs experienced higher rates of discontinuation due to medication availability throughout 2023 and into early 2024