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A randomized trial found that low-dose semaglutide significantly decreased: The amount of alcohol consumed during laboratory self-administration tasks 22 Weekly alcohol cravings compared to placebo 22 Drinks per drinking day 22 The magnitude of these effects appears substantial, with medium to large effect sizes for grams of alcohol consumed (, 0.48) and peak breath alcohol concentration (, 0.46) 22

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MC4R rs17782313 variants similarly influence melanocortin pathway sensitivity, affecting how strongly your hypothalamus responds to GLP-1's appetite-suppression signals

Neuroimage 15 , 273289 (2002)