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In Phase 3 trials so far, its delivered up to 28.7% body-weight loss at 68 weeks at the 12 mg dose in adults with obesity and knee osteoarthritis, alongside meaningful reductions in knee pain

35 They have been shown to help lower blood pressure, reduce postprandial lipemia, and decrease inflammation

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The clinical decision depends on availability, your medical history, and the protocol design

That dual mechanism helps explain why it can be especially effective for blood sugar control and weight loss