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This loss of GLP-1 secretion is part of the pathophysiological explanation for a lost incretin effect [13, 14], a phenomenon typically observed in patients with type 2 diabetes

The glucagon receptor is predominantly expressed in the liver

Reduces Liver Fat: In individuals with MASLD, retatrutide leads to profound reductions (over 80% at high doses) in liver fat and often normalization of hepatic fat contentchanges strongly linked to improved metabolic health 1

All pricing below comes from the company's landing page and was accurate at the time of this publication in February 2026

This steady sense of control makes it easier to avoid snacking, cut portion sizes, and maintain healthier eating habits without feeling deprived

C-peptide, a peptide released from pro-insulin to generate mature insulin, is a proxy measure for insulin release