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Common gastrointestinal side effects are the most frequently reported issues with GLP-1 therapy: Nausea and vomiting : Typically most pronounced during treatment initiation or dose escalation
doi: 10.1097/ALN.0000000000004776
The gut-microbiome-metabolism axis seems bidirectional, with GLP-1-producing L-cells reacting to microbial metabolites, especially butyrate and propionate
Differences between groups were assessed by one- or two-way ANOVA with time and treatment as covariants followed by Bonferronis post hoc multiple comparison testing as indicated in the figure legends
The Phase 2 trial reference point The Phase 2 retatrutide trial (Jastreboff et al., New England Journal of Medicine 2023) enrolled 338 adults across placebo and retatrutide arms at 1, 4, 8, and 12 mg weekly
When considering what to eat on Mounjaro or other GLP-1 therapies, focus should shift toward smaller, nutrient-dense portions that prioritise lean proteins and high-fibre vegetables
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