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The prediction of a safe outcome below the nomogram line corresponding to a 4-hour postingestion concentration of 150 micrograms/mL (1000 micromoles/L) was confirmed in patients who did not receive antidotal therapy

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doi:10.1016/S0021-9258(18)66917-0

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This phenomenon was especially noteworthy given the body of research linking the expression of Cx32, which is an essential structural protein in hepatocyte GJs, with the underlying mechanisms of liver toxicity induced by APAP