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The SURMOUNT-1 trial for tirzepatide showed average weight loss of 15% of starting body weight at 36 weeks (roughly 8.5 months)
Key drugs and the evidence that stunned clinicians Several GLP-1 RAs and related agents have been studied for weight management
Reported incidences included nausea (5.922.2%), diarrhea (8.825.3%), vomiting (2.99.1%), and constipation (8.816.2%), with discontinuation rates reaching 19% in high-dose monthly regimens (816 mg) [62,63,64]
Funding institutions The authors received no specific funding for this work
Instead, GIP may counteract nausea and vomiting via direct modulation of the area postrema/NST emesis circuitry (169) and exert protective effects on unfavorable altered gut motility (44)
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