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This hydroxylation step is tightly regulated by multiple endogenous factors

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The precursor, cleaved by a furin-like convertase in the trans-Golgi network, generates an extracellular ligand-binding subunit of 515 kDa (LRP1) and a transmembrane and intracellular subunit of 85 kDa (LRP1) [37]

Development of Preventive Interventions: In some studies, healthy volunteers are needed to evaluate vaccines, nutritional supplements, or other interventions aimed at preventing diseases rather than treating them

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