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*Correspondence: Tatsuro Kohno, [email protected] This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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A comprehensive immunogenicity assessment must evaluate peptide sequence foreignness, endosomal TLR signaling, linker stability, and synthetic impurity profiles as interconnected risk factors rather than as isolated considerations

In a study in 60 abdominally obese subjects with diminished GH, tesamorelin led to a reduction of 3.7lb in body fat from after 52 weeks of 2mg/daily administration

The clinical trials needed to establish safety and efficacy in this population are still underway

The CVOTs provide additional evidence for cardiovascular risk reduction with GLP-1RAs in patients with T2D