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The STEP 4 trial, which specifically examined semaglutide withdrawal, showed that participants who stopped the medication regained 6.9% of body weight over 48 weeks, while those who continued treatment lost an additional 7.9%

Trial-Based Protocol: The schedule below reflects the Phase 2 clinical trial protocol starting at 2mg

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Purpose-built for physicians Holding GLP-1RAs before endoscopy is justified to reduce risk for aspiration pneumonia Key takeaways: Glucagon-like peptide-1 receptor agonists were associated with a higher risk for aspiration pneumonia after endoscopy