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GLP-1 RAs are currently being explored for use in various new areas, such as cardiovascular disease, non-alcoholic steatohepatitis (NASH), Alzheimer's disease, and chronic kidney disease
doi: 10.1056/NEJMoa2028395 203 LoombaRHartmanMLLawitzEJVuppalanchiRBoursierJBugianesiEet al
However, when you look closer, many of the claims made are unverified , unrealistic , or flat-out misleading
Tan, who was not involved in the orforglipron trials
GLP-1 (glucagon-like peptide-1) helps regulate blood sugar, reduce appetite, and increase feelings of fullness, making it easier for patients to manage their weight
The mechanism of action is very imbalanced, since while it has a comparable GIP receptor binding affinity to native GIP, the affinity to the native GLP-1 receptor is five times lower [20, 21]
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