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Leptin has the ability to influence both innate and adaptive immune responses

P21 is a synthetic CNTF-derived peptide, modified with an adamantane group for stability

Its common to start treatment for a significant vitamin B12 deficiency with weekly intramuscular shots (1000 micrograms of vitamin B12)

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Thigh injections may produce more bruising due to higher muscle and vascular tissue density, while upper arm injections sometimes result in less visible marks if administered correctly

So we treat it pharmacologically and now they get this signal