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Patients should be counseled ahead of time that transient worsening of diabetic retinopathy or macular edema can happen whenever there is rapid glucose improvement, but that there are significant long-term benefits for diabetic retinopathy

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Despite its known toxicity, research on effective treatments remains limited

This triple agonism strategy builds upon the remarkable clinical success of dual GLP-1/GIP agonists like tirzepatide, which have shown unprecedented weight loss efficacy, by adding a third mechanism - glucagon receptor activation - to further enhance metabolic benefits, particularly energy expenditure and hepatic fat oxidation