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Our results on the liver injury of single time APAP overdose along with alcohol ingestion at different time scenarios relative to the overdose matched with the observation of clinical studies that shows that simultaneous ingestion of alcohol and APAP and intake of alcohol after APAP overdose for non-alcoholic individuals results in lesser production of NAPQI with decreased risk of hepatotoxicity (see Chien, Thummel, and Slattery 1997)

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matched for mean body weight at the start of treatment at 770 g 10 g) received daily IP injections of vehicle (1 mL/kg), sCT (3 g/kg), liraglutide (50 g/kg), a combination of sCT and liraglutide (3 g/kg + 50 g/kg) or a stepwise administration of the amylin and GLP-1R analogs, where rats received sCT treatment for the first week, liraglutide treatment for the second week, followed by a combination treatment of sCT and liraglutide for the remaining testing period

Differences between groups were examined for statistical significance by Students t-test unless otherwise stated