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Commonly, a neurotransmitter is considered to be a signaling molecule secreted by a neuron to affect another cell across a synapse [12,13,14]

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The combination of the amylin analogue pramlintide and the recombinant human leptin metreleptin caused significant weight reductions ( - 11.5kg) in comparison with monotherapy in a 24-week phase 2 clinical trial [248]

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Additionally, Pernicious anemia, an autoimmune condition affecting the stomachs ability to produce intrinsic factor (a protein necessary for B12 absorption), can also lead to deficiency