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Because Tirzepatide works on GLP-1 which slows digestion its side effects are very similar to other GLP-1 drugs: The good news tirzepatide does not cause hypoglycemia on its own

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Understanding these cardiovascular effects is essential for safe prescribing and monitoring, particularly in patients with baseline hypotension or those taking antihypertensive medications

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Using the GLP-QR agonist Exendin-4 (Exn-4) increased firing rates in arcuate nucleus (ARC) GLP-1R and POMC neurons, and the chemogenetic activation of ARC GLP-1R neurons significantly reduced food intake [132]

The addition of GLP-1 therapy does not change this reality unless the therapy continues