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Surg Oncol Clin N Am 7(3):603-16, 1998

It doesn't interrupt melanin production

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This mechanism increases intracellular concentrations of both NAD+ and SAM, two fundamental molecules that regulate cellular energy expenditure, mitochondrial function, and epigenetic modifications

CR induces suppression of INF pathways in DM Type II interferon signaling (IFN-g) is suppressed by CR

Cell Death Differ 29:10941106 Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman SC, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN (2018) Electrophilic properties of itaconate and derivatives regulate the ikappabzeta-atf3 inflammatory axis