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The International Society of Sports Nutrition position stand affirms creatine's safety profile in healthy individuals when used as directed

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It is a serious, chronic, progressive disease tied to type 2 diabetes, cardiovascular disease, hypertension, stroke, fatty liver disease, sleep apnea, kidney disease, certain cancers, joint disease, depression, reduced mobility, and a lower quality of life

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It is synthesized from the amino acids lysine and methionine and is primarily stored in skeletal muscles, the heart, and the liver