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Further CRISPR screening in MYCN-amplified neuroblastoma uncovered a dependency on polycomb repressive complex 2 (PRC2) components, particularly EZH2, which is transcriptionally activated by MYCN and suppresses neuronal differentiation [115]

Slower digestion

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bubalis (GenBank JN_887463) is truncated at position 477, caused by a point mutation in nucleotide 1431 which converts a Tryptophan (TGG) into a stop codon (TGA), resulting in a shorter and inactive tyrosinase gene

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After a 90 s read to establish a baseline, ligands (5 in assay buffer) were added online in the CellKey instrument and the changes of cellular impedance were measured over 60 min