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Indole acetic acid has been shown to be an important ligand for the aromatic hydrocarbon receptor (AhR), a ligand-activated transcription factor involved in the expression of enzymes that metabolize xenobiotics, inflammatory cytokines and adhesion molecules, all of which are mediators of inflammation in cardiovascular diseases (88)

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Targeted inhibition of microbial choline-TMAO conversion was also evaluated in a pressure overload mice model of heart failure, where it improved cardiac remodeling and cardiac function

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The Biology of Human Hair Greying