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The pathogenesis of MTX-induced renal impairment is thought to be mediated by either MTX and its metabolites precipitating in the renal tubules or MTXs direct toxic impact on the renal tubules (Reference Widemann and Adamson6)

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Semaglutide is GLP-1 areceptor agonist known for its ability to support metabolic function, improve blood sugar regulation, and promote balanced appetite signaling

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