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the critical factors are when the target is achieved and whether a relatively stable weight and metabolic state can be maintained during the discontinuation washout period
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Experimental investigations have demonstrated that cholangiocytes are sensitive to GLP-1 and respond with augmented proliferation, potentially increasing the risk of duct obstruction [47,48]
While Cardenas said his husband, Jeffer Jimenez, 37, uses GLP-1s primarily for weight loss, Jimenezs prescription is for his diabetes, so the couple hoped to continue receiving coverage through Medi-Cal
Patients are typically instructed by their clinician or dispensing pharmacy on how to prepare and administer each dose
For the efficacy estimand, the LSM change in HbA1c from baseline at week 52 as the primary endpoint was 2.24%, 2.43%, and 2.58% with tirzepatide 5, 10, and 15 mg, respectively, versus 1.44% with insulin glargine
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