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Institute of Medicines Recommendations In their 1998 report, the IOM used the amount of B12 required to treat pernicious anemia as a basis for their recommendations for the general adult population (IOM, 1998)

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In aged rodents, the same pharmacology has been extended to skeletal-muscle pathology, where it preserves muscle stem cell function and mitigates sarcopenia [3]

The B-Complex does hurt and I have a high tolerance to pain