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Garcia-Echeverria et al (2004) presented a new compound (a pyrrolo[2,3-d] pyrimidine) that although inhibiting the IGF-1R and IR TK equipotently in cell-free systems, exhibited several-fold selectivity for the IGF-1R in a cellular context and reduced the growth of IGF-1R positive fibrosarcomas in vivo

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People with untreated hypothyroidism should delay sermorelin until their thyroid condition is managed, because low thyroid hormone levels can make sermorelin ineffective (thyroid hormone is important for growth hormone action)

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