Published pre-clinical studies have used FOXO4-DRI to demonstrate that selective elimination of senescent cells in aged mouse models can improve a range of tissue function parameters including fitness, fur density, renal function, and liver function establishing the broader research principle that senescent cell burden contributes meaningfully to ageing tissue dysfunction and that its targeted reduction produces measurable functional benefits in experimental models
Studies have found that berberine attenuates ischemia-reperfusion injury through NF-B nuclear translocation in mice with transient cerebral artery occlusion, however, this neuroprotective effect was more pronounced at the high dose (50 mg/kg) than the low dose (25 mg/kg) (Zhu et al., 2018)
For instance, the addition of spirulina to low protein chicken diets resulted in reduction of systemic inflammation and bacterial translocation indicating its suitability as a alternative protein source (73)
Energy Restoration: B-Vitamins (especially B12) help combat the extreme lethargy and "heaviness" that come with being sick
Glutathione helps control and balance the bodys inflammatory response, instructing immune cells to reduce inflammation once its no longer needed
Pharma Nutr (2023) 11:100342