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We found consistent downregulation of GPX3 expression by TNF- in both cell types, both on transcript and on secreted protein level (Figs 7A and 8A)

Dietary antioxidants derived from fruits, vegetables, and medicinal plants may function as chemopreventive agents by reducing oxidative stress and lipid peroxidation in vulnerable populations [106]

Further studies are needed to clearly understand the biological effects of Se supplementation, considering baseline Se levels, selenoprotein gene polymorphisms, comorbidities, and main clinical outcomes (89)

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