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They are ago-allosteric modulators of hGLP-1R, since they can act both as independent agonists but also as allosteric enhancers of the activity of the natural agonist

A chimeric inhibitor that binds the affinity recognition moiety to a chelated transition metal has been explored to develop metal-mediated affinity reagents or drugs for hGSTP1-1 (34)

"Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial"

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[ CrossRef ] [ Google scholar ] [ PubMed ] Severyanova L, Dolgintsev ME

Pearson, 2005)