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Mechanistic studies have revealed that the application of Gln metabolic inhibitors or the knockdown of the transmembrane protein SLC1A5 can inhibit the YAP1/TEAD signaling cascade, which is known to promote mesothelioma invasion and metastasis ( 2.1.2 Promoting drug resistance in tumor cells The dysregulation of Gln metabolism is closely associated with the development of tumor resistance ( In ovarian cancer, the levels of Gln, glutamate, and GSH in the cisplatin-resistant cell line A2780cis were significantly higher than those in the A2780 cells, while the expression of GS decreased

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10.3390/biomedicines13020413 42 Chronic Complications of Diabetes Mellitus (2024)

Safety Information/Precaution Consult a healthcare professional before starting any new supplement regimen, especially if you are pregnant, nursing, or have any underlying medical conditions

The sample was then filtered with a nylon filter with a pore size of 0.2 m and centrifuged in microtubes equipped (20,000 g, 10 min, 4 C)