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At an optimal ratio, the combination elevated collagen IV synthesis by 25.4 times in cell models and 2.03 times in ex-vivo skin tissue compared to controls

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They are discussed for overlapping reasons, but they come from different biological concepts, are studied through different mechanisms, and raise different safety and regulatory questions

(2) When studied together in vitro, TB-500 and BPC-157 have been observed to overlap in some functional areas and complementary actions