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PIONEER 6 compared oral semaglutide to placebo in 3183 patients with T2DM and established CV disease or CV risk factors only [21]

Fast-Tracked Drugs Are More Likely to Have Boxed Warnings Drugs that the FDA gives fast-track status to are more likely to receive a boxed warning after they hit the market, according to a 2017 study by Andreas Schick and colleagues

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[68] Gastrointestinal side effects may include dry mouth, constipation, and increased appetite, which are generally attributed to the medications anticholinergic and antihistaminergic properties

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