convert semaglutide to tirzepatide Efficacy of 5, 10 and 15 mg versus 2 mg in patients with type 2 diabetes: An adjusted indirect treatment comparison Switching Semaglutide to Tirzepatide |

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In some cases, improved insulin sensitivity may actually support metabolic health

Heart rate increases slightly more with tirzepatide (average 2-3 bpm) than with semaglutide, but this change has not translated to increased cardiac events in published trials