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These pathways were selected because they correspond to the core biological foundations of neurodegenerationproteinopathy, synaptic disfunction, neuroinflammation, mitochondrial impairment, vascular and metabolic dysregulation, among othersthereby anchoring the workflow in mechanisms that are central to dementias and making it applicable across AD, FTD, DLB, vascular and mixed dementias, as well as related neurodegenerative phenotypes that share these pathogenic mechanisms

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For instance, sulfated glycosaminoglycans (GAGs) in the gut is necessary for preventing leaky gut and maintaining nutrient absorption, as well as regulating cholecystokinin and gastrin (intestinal hormones)

1 The incidence of antibody formation has been shown to decrease with time (over 3 years)