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(2) the ability of the TJ to selectively allow paracellular transport of certain ion species acting as ion channel and (3) the ability of the TJs to maintain cell polarity, by blocking the free diffusion of proteins and lipids between the apical and basolateral domains of the plasma membrane

10.1016/j.lfs.2017.08.006 88 StupnisekM.KokotA.DrmicD.Hrelec PatrljM.Zenko SeverA.KolencD.et al (2015)

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The peptide works best as part of a comprehensive approach

Unlike many sedatives, DSIP does not induce dependency, and its effects are generally restorative rather than suppressive