glp 1 receptor brain GLP-1 agonists show promise in treating substance use disorders Mechanisms of GLP-1 in Modulating

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10.1038/s41574-022-00783-3 31 HavranekB.LohR.TorreB.RedfieldR.Halegoua-DemarzioD

Patients who switched from tirzepatide to orforglipron maintained a mean 74.7% of their body weight reduction from the SURMOUNT-5 trial compared with those in the placebo group, which maintained a mean 49.2% of their weight loss

Studies have shown that variations in the GIPR gene are linked to cardiovascular disease and metabolic syndrome characteristics, which supports this idea [110]

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