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In 2022, Eli Lilly launched its first in-class diabetes drug called Mounjaro (generic name tirzepatide), which activates both GLP-1 and GIP receptors for increased blood glucose control

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Concurrently, histone Kla in TAMs elevates IL-10 production, a cytokine that induces T-cell anergy through PD-1/LAG-3 upregulation (72)

The SELECT cardiovascular outcomes trial, whose results were fully incorporated into regulatory labeling by 2024, directly catalyzed a new wave of prescribing for semaglutide in cardiology settings, materially broadening the addressable API volume requirement