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Surg Obes Relat Dis 14(9):13681372 Brown AM, Yang J, Zhang X, Docimo S, Pryo AD, Spaniolas K (2022) Bariatric surgery lowers the risk of major cardiovascular events

Bloating is often most noticeable in the first few weeks or after a dose increase

GLP-1 binds to receptors (GLP-1R) in the hindbrain, hypothalamus, lateral septum and cortex, engaging circuits that inhibit food intake (extensively reviewed in previous work 8 )

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Research shows that combining GLP-1 with resistance training (23 sessions per week) preserves muscle mass during weight loss better than medication or diet alone

Some users notice subtle improvements in sleep quality, energy, or mood, but dramatic changes are not typical this early