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Cell Chem Biol 30(3):321336e6

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10.1080/13813455.2019.1628079 20 EMA (2023)

Principal component analysis (PCA) was plotted using R program.To adjust for the confounding demographic significantly different in age and BMI of patient, binary logistic regression was conducted to confirm differences in metabolite abundance in the three groups

Hypoxia stops the degradation of HIF-1, which lets HIF-1 attach to hypoxia-responsive parts of oxygen-regulated genes when hypoxia is present