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Aggregated -synuclein fibrils, dopamine-derived quinones, and mitochondrial DAMPs, including cardiolipin and mtDNA, are strong inducers of microglial NLRP3 inflammasome activation in PD
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These shifts establish a temporary immune window conducive to sperm preservation and initial embryo reception
For those considered overweight or having obesity, losing 5% or more of initial weight is linked to lessening cardiometabolic disease risk, with reductions in blood pressure, LDL cholesterol, triglycerides, and glycemia
Furthermore, considering the possibility of a 20% dropout rate, we calculated the sample size as 20 individuals per group