It is plausible that excessive ROS from other metabolic disorders (such as obesity, insulin resistance, and elevated LDL-cholesterol and low HDL-cholesterol) can induce a state of chronic low-grade inflammation (e.g., raising IFN- and TNF-), possibly aggravating or activating vitiligo in genetically predisposed individuals, as illustrated in Figure 1
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Although improved insulin sensitivity was an outcome of this study, this cannot be generalized to a human population due to the use of mice, as well as the lack of whole-body insulin sensitivity measures
Key takeaways Some individuals using Wegovy may develop an altered sense of taste, often described as metallic or unpleasant, though this side effect was not commonly reported in clinical trials
Use qualified, trained providers, maintain sterile technique, conduct proper patient screening, and follow strict aftercare protocols
