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Though the insurance coverage of GLP-1s remains spotty, Novo and Eli Lilly (makers of tirzepatide, the other major GLP-1 on the market) have steadily lowered the out-of-pocket cost of their drugs, particularly this year

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2014: Dulaglutide (Trulicity) is approved by the FDA, and is recognized as the first type 2 diabetes drug to reduce the risk of major adverse cardiovascular events (MACE)

23 In addition, for many decades increased immunostaining with antibodies against glial fibrillary acidic protein (GFAP) has been regarded as a universal molecular marker of astrocyte reactivity

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