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Mitochondria execute myriad vital cellular processes including fatty acid oxidation, urea cycle, Krebs cycle, biosynthesis of heme and steroids, maintenance of calcium homeostasis, caspase-dependent apoptosis, reactive oxidant species (ROS) generation, and heme and steroid synthesis [12,13]

W.PalkovitsM.et al

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Heme oxygenase 1 catalyzes the degradation of heme to free iron, biliverdin, and carbon monoxide (CO) thereby removing free heme which is pro-oxidant