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In addition to obesity, IR and diabetes, TMAO is also reported associated with other metabolic dysregulations that related to MAFLD, including dyslipidemia ( The Underlying Mechanisms of TMAO in the Development of MAFLD Although TMAO has been shown to be linked to MAFLD, the molecular mechanisms of TMAO remain obscure

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The primary antioxidant mechanism involves donating an electron from the sulfhydryl (-SH) group of the cysteine molecule